Study published in the Journal of Urology (J Urol. 2012 Jun;187(6):2268-74) showing the results of using xiaflex.
It was seen that the injection of xiaflex, without any other mechanical intervention, did not result in an improvement in curvature. Only in the group in which xiaflex was injected + modeling (mechanically forcing the penis to the opposite side) was there an improvement of 11 degrees at the end. This was a percentage improvement of 29.7% on the original curvature.
This study shows what was already known. That xiaflex is not a panacea that will solve the problem of patients with Peyronie's disease. It may be a solution for patients who have a small deformity, something less than 20-30 degrees of deviation.
I see many patients misinformed about xiaflex, thinking it's the solution to their problems. It's a common comment when patients arrive for their consultation.