Journal of Sexual Medicine. 2015;12: 248-258.
Another good piece on the use of Xiaflex.
347patients took part in the study. They received up to 8 injections of xiaflex and were followed by 36 weeks
The initial average curvature was 53o. After 36 weeks of follow-up, the final mean curvature was 34.7oThis represents an improvement of 18,3o (or 34,4%) of penile curvature.
We know that the placebo effect (use of saline solution instead of Xiaflex) creates an 18.2% improvement in curvature (Gelbard M, et al. J Urol. 2013 Jul;190(1):199-207). So if we use xiaflex in a patient with 45o of curvature he will have a final result of 29,5o deviation (improvement of 34,4%). If we use saline (placebo) instead of xiaflex, the result will be 36,8o deviation (improvement of 18,3%). To help visualize the result Xiaflex vs. Placebo I'll put an image of the results previously quoted at the end of this text.
As can be seen in the figure below, the use of Xiaflex doesn't seem to have made such a big difference to the placebo. Although there is strong scientific evidence that Xiaflex works better than placebo, I don't think it effectively rectifies penile curvatures, especially in more severe cases (> 60o).
We must also remember that the medication is expensive. In the United States, each dose costs an average of $3,300.00 per application. This means that in 8 applications the final cost of the treatment will be $ 26,400.00.
The medication has not yet been released for use in Brazil.
